近年来，他的团队一直在关注Hippo通路及其在癌症中的作用，在推动Hippo领域方面发挥了领导作用。

截至目前，管坤良 已发表300多篇研究论文，是分子生物学和遗传学领域被引用最多的研究人员之一（H指数167，谷歌学术），同时也是在Hippo领域被引用最多的学者和在mTOR领域被引用第二多的学者。 曾获评美国“麦克阿瑟天才奖”、美国生物化学和分子生物学学会“青年科学家奖”和华人生物学家协会吴瑞奖等多个重要奖项。

加入西湖大学后，管坤良将组建“分子细胞生物学实验室”，聚焦于Hippo通路调控的分子机制、上游信号、生理功能以及其在癌症中的作用。目前实验室已正式启动招聘。

联系方式：

E-mail：guankunliang@westlake.edu.cn

Website:

https://www.westlake.edu.cn/faculty/kunliang-guan.html

代表论文：

1. Inoki, K., Zhu, T., and Guan, K-L.（2003） TSC2 mediates cellular energy response to control cell growth and survival.  Cell 115, 577-590.

2. Inoki, K., Ouyang, H., Zhu, T., et al, Williams, B., and Guan, K-L. （2006）TSC2 integrates Wnt and cellular energy signals through a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell 126, 955-68.

3. Kim, E., Goraksha, P., Li, L., Neufeld, T.P., and Guan, K-L. （2008）Regulation of TORC1 by Rag GTPases in nutrient response. Nature Cell Biol. 10, 935-945.

4. Zhao, S., Xu, W., Jiang, W., et al, Q., Xiong, Y., Guan, K-L.,（2010）Regulation of cellular metabolism by protein lysine acetylation.  Science 327, 1000-1004.

5. Kim, J., Kundu, M., Viollet, B., and Guan, K-L., （2011）AMPK and mTOR regulate autophagy via direct phosphorylation of ULK1. Nature Cell Biol. 13, 132-141. 

6. Yu, F-X., Zhao, B., Panupinthu, N., Jewell, J. L., Wang, L., Zhao, J., Yan, H., Tumaneng, K., Li, H., Fu, X-D., Mills, G. B., and Guan, K-L. （2012） Regulation of the Hippo-YAP pathway by G-protein coupled receptor signaling. Cell 150, 780-91.

7. Russell, R.C., Tian, Y., Yuan, H., Park, H.W., Chang, Y.Y., Kim, J., Jim, H., Neufeld, T., Dillin, A., Guan, K-L. （2013）ULK1 induces autophagy by phosphorylating Beclin-1 and activating Vps34 lipid kinase.  Nature Cell Biol. 15, 741-50.

8. Zhao, D., Zou, S-W., Liu, Y., Zou, X., Mo, Y., Wang, P., Xu, Y-H., Dong, B., Xiong, Y., Lei, Q-Y., and Guan, K-L. （2013）Lysine-5 acetylation negatively regulates lactate dehydrogenase A and is decreased in pancreatic cancer. Cancer Cell, 23, 464-476. 

9. Kim, J., Kim, Y.C., Fang, C., Russell, R.C., Kim, J.H., Fan, W., Liu, R., Zhong, Q., and Guan, K-L. （2013）Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy.  Cell 152, 290-303.

10. Yu, F.X., Luo, J., Mo, J-S., Liu, G., Kim, Y.C., Meng, Z., Zhao, L., Peyman, G., Ouyang, H., Jiang, W., Zhao, J., Chen, X., Zhang, L., Bastian, B.C., Zhang, K. and Guan, K-L. （2014）Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP. Cancer Cell 25, 822-830. 

11. Jewell, J.L., Kim, Y.C., Russell, R.C., Yu, F.X., Park, H.W., Plouffe, S.W., Tagliabracci, V.S., and Guan, K-L. （2015） Differential Regulation of mTORC1 by Leucine and Glutamine. Science 347, 194-198.

12. Yu, F.X., Zhao, B., and Guan, K-L. （2015）Hippo pathway in organ size control, tissue homeostasis, and cancer.  Cell 163, 811-828.

13. Park, H. W., Kim, Y.C., Yu, B., Moroishi, T., Mo, J-S., Plouffe, S.W., Meng, Z., Lin, K.C., Yu, F.X., Alexander, C.M., Wang, C., and Guan, K-L. （2015）Alternative Wnt Signaling Activates YAP/TAZ. Cell 162, 780-794.

14. Moroishi, T., Hayashi, T., Pan, W.W., Fujita, Y., Holt, M.V., Qin, J., Carson, D.A., and Guan, K-L. （2016）The Hippo pathway kinase LATS1/2 suppress cancer immunity. Cell 167, 1525-39.

15. Lin, K.C., Moroishi, T., Meng, Z., Jeong, H., Plouffe, S.W., Sekido, Y., Han, J., Park, H.W., Guan, K-L. （2017）. Regulation of Hippo pathway tranion factor TEAD by p38 MAPK-induced cytoplasmic translocation. Nature Cell Biol. 19, 996-1002.

16. Meng, Z., Qiu, Y., Lin, K.C., Kumar, A., Placone, J.K., Fang, C., Wang, K-C., Lu, S., Hong, A.W., Pan, M.,  Moroishi, T., Luo, M., Plouffe, S.W., Diao, Y., Ye, Z., Park, H.W., Wang, X., Yu, F-X., Chien, S., Wang, C-Y., Ren, B., Engler, A.J., and Guan, K-L. （2018）RAP2 mediates mechno-responses of Hippo pathway. Nature 560, 655-660.

17. Chen, R., Xie, R., Meng, Z., Ma, S., Guan, K-L. （2019）. STRIPAK integrates upstream signals to initiate the Hippo kinase cascade. Nature Cell Biol. 21, 1565-1577.

18. Luo, M., Meng, Z., Moroishi, T., Lin, K.C., Shen, G., Mo, F., Shao, B., Wei, X., Zhang, P., Wei, Y., Guan, K-L. （2020）Heat stress activates YAP/TAZ to induce the heat shock tranome. Nature Cell Bio. 22, 1447-59.

19. Ma, s., Wu, Z., Yang, F., Zhang, J., Johnson, R.L., Rosenfeld, M.G., and Guan, K-L. （2021）Matters Arising：Hippo signaling maintains ER expression and ER+ breast cancer growth. Nature 591, E1-E10.

20. Li, F.L., Fu, V., Liu, G., Tang, T., Koradi, A., Peng, X., Kemper, E., Cravatt, B.F., Franklin, J.M., Wu, Z., Mayfield, J., Dixon, J.E., Gerwick, W.H., and Guan, K-L. （2022）Regulation of the Hippo pathway by phosphatidylinositol transfer protein（PITP）and phosphoinositides. Nature Chem. Biol. 18, 1076-1086.