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南加大Keck医学院石善溶教授获美国组织化学学会终生荣誉会员奖
南加大Keck医学院石善溶教授获美国组织化学学会终生荣誉会员奖
2017/6/3 23:56:11 | 浏览:1596 | 评论:0

 南加大Keck医学院石善溶教授获美国组织化学学会终生荣誉会员奖

2017423日在芝加哥举行的美国组织化学学会(HCS)的年会上,南加大Keck医学院病理学系教授石善溶获得美国组织化学学会终生荣誉会员奖(HCS Honorary Lifetime Member)。

HCS出版的简报中,学会授奖委员会指出:石教授在1957年毕业于华西医科大学。他的主要科学贡献是发明加热抗原修复技术,这一简单有效的方法使得常规甲醛固定石蜡包埋的组织能够被用于免疫组织化学染色,迅速在全球的所有形态学领域里广泛推广,被誉为病理学界的革命性突破,是免疫组织化学的一座里程碑。

近年来,这一技术已经进一步被用于从石蜡组织中提取蛋白质,核酸等以供分子生物学分析之用,如免疫凝胶电泳,蛋白质谱分析,PCR等。抗原修复技术所提供的最大效益在于打开了收藏在全世界为数众多实验室中的石蜡组织块宝库的大门,成为科学家们手中的一把金钥匙,能够使用这些极有研究价值而又无法取代的珍贵标本,不仅可以进行免疫组化染色,而且可以进行现代分子学分析。为此,他于2011年获得HCS的最高奖乔治戈摩利奖。

此外,HCS还介绍了石教授担任组织化学和细胞化学杂志、应用免疫组织化学与分子形态学杂志,以及中华病理学杂志的编委。2006-2010年间担任HCS的常务理事等。

 

HCS Honorary Lifetime Member – Shon-Rong Shi

Histochemical Society(HCS)

Dr. Shi received his MD degree from West China University of Medical Sciences, Chengdu, China, in 1957. The early years of his career were spent as an ENT doctor at the same university in China. Because of his research project in nasopharyngeal carcinoma, he was sent to the Department of Pathology of the same university to have extensive pathology training for one year. This experience provided the solid foundation for his future study in pathology.

In early 1980, he passed a national examination and obtained a scholarship provided by Chinese government to study abroad. He was sent to Massachusetts General Hospital as a Visiting Scholar from 1982 to 1984. It was during this time that he started his life-long interest in the application and development of immunohistochemistry(IHC).

He returned to China in 1985 and published his first book entitled "Techniques of IHC" which was also the first IHC book in China. In early 1990s, he successfully developed the antigen retrieval(AR)technique which expands the application of IHC from largely frozen tissue only to formalin-fixed, paraffin-embedded(FFPE)tissue. AR has been recognized as a milestone in IHC and a revolutionary breakthrough in pathology.

Dr. Shi worked as a faculty member at Department of Pathology, University of Southern California since 1992 and retired in 2012. He published more than 70 articles and three books in AR. Because of his contribution and endeavor in the development of AR technique and IHC, he received the George Gomori Award on March 31, 2011 at the 62nd Annual Meeting of The Histochemical Society(HCS). Dr. Shi served as an Associate Editor of Journal of Histochemistry and Cytochemistry(JHC)(2003-2012), Editorial Board members of JHC, Applied Immunohistochemistry and Molecular Morphology, and Chinese Journal of Pathology. He was a Councilor of HCS from 2006 to 2010.

His major research interest is focusing on AR techniques as well as extending application of this AR technique in extraction of proteins and nucleic acids from FFPE tissue sections, and tissue proteomics.

 

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